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讲准字226号:Measuring aflatoxin exposure in six African countries

发布时间:2018-07-02|浏览次数:

题目:Measuring aflatoxin exposure in six African countries

主讲:宫芸芸

时间:2018年7月4日 15:00

地点:食品学院203会议室

主办:食品与生物工程学院


主讲简介:宫芸芸,英国利兹大学副教授。研究专长:食品安全。宫芸芸,2000年毕业于中国预防医科院,获博士学位,现为英国利兹(Leeds)大学食品科学与营养学院副教授,2017年受聘我校兼职教授。宫博士长期从事食品卫生的教学和科研工作,研究方向主要为食品霉菌毒素的安全性评价和人群预防措施。近年来先后独立承担英国皇家协会、维康基金会、美国国家环境科学研究院(NIEHS)、WHO肿瘤研究机构(IARC)、其它慈善基金会的多项课题,致力于儿童人群霉菌毒素暴露水平和健康效应评价和健康效果的机制研究和干预。宫博士与世界知名研究机构如Johns Hopkins大学、伦敦热带病医学研究所(LSHTM)、IARC、南非医学研究署有多项合作项目,目前是利兹大学食品霉菌毒素科研组的带头人。作为学科领域的学术带头人,先后承担国际研究项目7项,在国际该领域杂志上发表论文近40篇,参与著书4册,被多次邀请参加国际学术会议并作报告。应邀在康奈尔大学、比尔盖茨基金会专家研讨会上做重要学术讲座,目前是世界霉菌毒素研究学会成员、英国环境突变学会成员、英国肿瘤研究学会会员、中国食品毒理学会会员。

 

主讲内容:Aflatoxins are carcinogenic, they have been implicated to have other adverse health impacts, including child growth impairment and immune function suppression. Aflatoxin B1 is the most toxic and most common of the aflatoxins. Contamination of various food crops is common in sub-Saharan Africa, particularly in maize and groundnuts, leading to chronic dietary exposure in many populations. For many years we have used the aflatoxin albumin adduct as a biomarker of aflatoxin exposure, assessed using a competitive inhibition enzyme linked immunosorbent assay (ELISA). Our recent studies of human exposure in six African countries; Gambia, Guinea, Kenya, Senegal, Tanzania and Uganda shows the widespread exposure of vulnerable populations to aflatoxin. Geometric mean (95% confidence interval) levels of the biomarker ranged from 9.7 pg/mg (8.2, 11.5) in Ugandan children to 578.5 pg/mg (461.4, 717.6) in Kenyan adolescents during an acute aflatoxicosis outbreak year. Various factors may have influenced the variation in aflatoxin exposure. Together, these studies highlight the urgent need for interventions to reduce the burden of aflatoxin exposure in sub-Saharan Africa.


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